Science and Technology Notes for UPSC and state exams

✅ Topics and Sub-topics: 300+
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✅ Mains Relevance: ✰✰✰✰✰
✅ Average student rating: ✰✰✰✰✰
✅ Difficulty Level: Moderate
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Evolution of the Earth and Processes
Biotechnology

Genetic Engineering: Principles, Tools, and Applications

Recombinant DNA Technology: Tools, processes, and applications

CRISPR-Cas9: Mechanism, ethical considerations, and applications in gene editing

Synthetic Biology: Designing and constructing new biological systems

Gene Therapy: Types,  Mechanisms, and Advancements

Genome Sequencing: Types, Techniques, and Implications

Human Genome Project: Achievements and prospects

Biofilms: Structure, functions, Formation, Challenges, and Applications

Polymerase Chain Reaction (PCR): Types, Principles and Applications

Genetically Modified (GM) Crops: BT Cotton, BT Brinjal, GM Mustard, and their socio-economic implications.

Marker-Assisted Breeding: Accelerating crop improvement.

Biofortification: Enhancing nutritional value in crops (e.g., Golden Rice).

Bioremediation and Biofuels

Waste Management: Composting, biodegradation, and recycling

RNA Interference (RNAi): Mechanism and Applications

Enzyme Technology: Production and industrial applications (e.g., detergents, food processing)

Biopharmaceuticals: Production of insulin, vaccines, and monoclonal antibodies

Bioplastics: Sustainable alternatives to conventional plastics

DNA Barcoding: Techniques, Principles, and Uses

DNA Fingerprinting: Principles, Techniques, and Applications

Applications of Biotechnology in Medicine: Diagnostics, Therapeutics, and Pharmacogenomics

CAR T-Cell Therapy: Principles, Mechanism and Applications

Biotechnology in Disease Management: Antimicrobial Resistance (AMR) and Vaccine Development

Stem Cell Technology: Types, Principles, and Applications

Bioinformatics: Tools and Applications

Biotechnology in Food Processing: Fermentation and Food Preservation

Biotechnology in Climate Change Mitigation: Carbon Capture and Climate-Resilient Crops

Biotechnology in Space Exploration: Astrobiology and Space Agriculture

Emerging Trends in Biotechnology: Synthetic Vaccines, Organ-on-a-Chip, and AI in Biotechnology

Ethical, Legal, and Social Implications (ELSI) of Biotechnology

NanoTechnology
Biology

Cell Biology

Cell Organelles: Plant Cell & Animal Cell

◐ Cell Membrane Structure and Function

◐ Transport: Diffusion, Osmosis, Active Transport

Signal Transduction and Cell Communication

◐ Apoptosis and Programmed Cell Death

◐ Cellular Respiration and Energy Production

Photosynthesis: Light and Dark Reactions

Human Physiology

Human Digestive System 

◐ Human Respiratory System

◐ Human Circulatory System

◐ Blood and blood groups

◐ Human Excretory System

◐ Endocrine glands and Hormones

◐ Human Brain and Nervous System

◐ Muscular and Skeletal System

◐ Human Reproductive System

◐ Human Immune System

Microbiology

Diseases Caused by Microorganisms

Microbes in Human Welfare  & Useful Microbes

Antibiotic Resistance and Its Mechanisms

Virology: Structure and Classification of Viruses

◐ Bacteriology: Structure and Function of Bacteria

Mycology: Study of Fungi and Their Applications

Animal Biology

◐ Animal Tissues: Epithelium, Connective Tissues

◐ Classification of Animal Kingdom (Animalia)

◐ Classification of Vertebrata (Phylum Chordata)

◐ Comparative Anatomy and Physiology

◐ Animal Behavior and Ethology

◐ Animal Adaptations to Extreme Environments

Human Health and Nutrition

◐ Balanced Diet and Nutritional Requirements

◐ Malnutrition: Causes, Effects, and Solutions

◐ Food Fortification and Biofortification

◐ Nutrigenomics and Personalized Nutrition

◐ Gut Microbiome and Its Role in Health

Emerging Topics in Biology

◐ Synthetic Biology and Artificial Life

Bioinformatics and Computational Biology

Systems Biology and Network Analysis

Epigenetics and Gene Regulation

Molecular Diagnostics and Precision Medicine

Space Biology: Effects of Space on Living Organisms

Astrobiology: Search for Extraterrestrial Life

Biomolecules

◐ Biomolecules: Carbohydrates, Monosaccharides, Polysaccharides

Proteins, Amino Acids, and  Enzymes

◐ Lipids: Trans Fat, Saturated & Unsaturated Fats, Healthy & Unhealthy Fats

◐ Nucleic Acids: DNA, RNA, and Recombinant DNA

Vitamins, Minerals, and  Deficiency Diseases

◐ Water: Structure, Properties, and Biological Importance

Genetics and Molecular Biology

◐ Mitosis, Meiosis, Cell Cycle, and Cell Division

◐ Inheritance: Mendel’s Laws of Inheritance

◐ Chromosomal Theory & Human Genome Project

◐ Sex Determination & Genetic Disorders

◐ Molecular Basis of Inheritance: DNA Replication, Transcription, and Translation

◐ Genetic Engineering: Processes and Applications

◐ CRISPR-Cas9 and Genome Editing

Plant Biology

◐ Plant Parts and Their Functions

◐ Plant Kingdom: Thallophytes (Algae), Bryophytes, & Pteridophytes

◐ Plants with Seeds: Gymnosperms and Angiosperms

◐ Plant Tissue: Meristematic, Simple, Complex Permanent Tissue

◐ Plant Nutrition: Photosynthesis, Nitrogen Cycle and Fixation

◐ Sexual and Asexual Reproduction in Plants

◐ Plant Hormones and Their Functions

◐ Plant Defense Mechanisms Against Pathogens

◐ Insectivorous Plants of India: Drosera, Pitcher Plant, and Utricularia

Diseases and Health

◐ Diseases: Acute, Chronic, Communicable Diseases

◐ AIDS: Acquired Immune Deficiency Syndrome

◐ Cancer: Causes of Cancer

◐ Drugs and Alcohol Abuse

◐ Non-Communicable Diseases: Diabetes, Cardiovascular Diseases

◐ Zoonotic Diseases and One Health Approach

◐ Vaccines: Development and Mechanisms of Action

◐ Biological Pest Control and Integrated Pest Management

◐ Aquaculture and Sustainable Fisheries Bioenergy and Biofuels: Production and Challenges

◐ Bioplastics and Sustainable Materials

◐ Biological Warfare and Biosecurity

Ethical and Social Issues in Biology

◐ Ethical Issues in Genetic Engineering and Cloning

◐ Biopiracy and Intellectual Property Rights in Biology

◐ Biosafety and Regulatory Frameworks

◐ Public Perception and Awareness of Biotechnology

Chemistry

Basic Concepts of Chemistry

Atomic Theory – Structure of an Atom

Elements, Metalloids, Compounds, Mixtures vs. Compounds

Molecule, Ion, Molecules of Elements & Compounds, Atomicity

Laws of Chemical Combination: Law of Conservation of Mass, Law of Definite Proportions

Dalton’s Atomic Theory and Its Limitations

Modern Periodic Table: Trends and Periodicity

States of Matter

◐ Solid State: Crystalline and Amorphous Solids

◐ Liquid State: Properties and Behavior of Liquids

◐ Gaseous State: Gas Laws, Kinetic Theory of Gases

◐ Plasma and Bose-Einstein Condensate

Atomic Structure and Chemical Bonding

◐ Subatomic Particles: Protons, Neutrons, Electrons

◐ Quantum Mechanical Model of the Atom

◐ Electronic Configuration and Aufbau Principle

◐ Types of Chemical Bonds: Ionic, Covalent, Metallic

◐ Hydrogen Bonding and Its Significance

VSEPR Theory and Molecular Geometry

Redox Reactions

◐ Oxidation and Reduction

◐ Balancing Redox Reactions

◐ Electrochemical Cells and Electrolysis

◐ Corrosion and Its Prevention

Surface Chemistry

◐ Adsorption and Absorption

◐ Catalysis: Homogeneous and Heterogeneous

◐ Colloids and Their Properties

◐ Emulsions and Their Applications

Chemical Kinetics

◐ Rate of Reaction and Factors Affecting It

◐ Rate Law and Order of Reaction

◐ Activation Energy and Arrhenius Equation

◐ Catalysts and Their Role in Reactions

Industrial Chemistry

◐ Chemical Industries: Fertilizers, Pesticides, Dyes

◐ Petrochemicals and Their Applications

◐ Cement, Glass, and Ceramics

◐ Pharmaceutical Chemistry: Drug Design and Development

Nuclear Chemistry

◐ Radioactivity: Alpha, Beta, and Gamma Decay

◐ Nuclear Reactions: Fission and Fusion

◐ Applications of Radioisotopes

◐ Nuclear Power and Its Environmental Impact

Nanochemistry

◐ Synthesis of Nanoparticles

◐ Properties and Applications of Nanomaterials

◐ Nanotechnology in Medicine and Industry

Chemical Reactions and Equations

◐ Types of Chemical Reactions: Combination, Decomposition, Displacement, Redox

◐ Balancing Chemical Equations

◐ Stoichiometry and Mole Concept

◐ Limiting Reagents and Percent Yield

Thermodynamics and Thermochemistry

Laws of Thermodynamics

◐ Enthalpy, Entropy, and Gibbs Free Energy

◐ Heat Capacity and Specific Heat

◐ Thermochemical Equations and Hess’s Law

Chemical Equilibrium

◐ Reversible and Irreversible Reactions

◐ Le Chatelier’s Principle

◐ Equilibrium Constant and Its Applications

◐ Acid-Base Equilibria: pH, pOH, and Buffers

Acids, Bases, and Salts

◐ Arrhenius, Bronsted-Lowry, and Lewis Theories

◐ Properties of Acids and Bases

◐ pH Scale and Its Importance

◐ Types of Salts and Their Uses

Organic Chemistry

Classification of Organic Compounds

IUPAC Nomenclature

Isomerism: Structural and Stereoisomerism

◐ Functional Groups and Their Reactions

◐ Hydrocarbons: Alkanes, Alkenes, Alkynes

◐ Aromatic Compounds and Huckel’s Rule

Polymers

◐ Classification of Polymers: Natural and Synthetic

◐ Polymerization Reactions: Addition and Condensation

◐ Important Polymers: Polyethylene, PVC, Nylon, Teflon

◐ Biodegradable Polymers and Their Applications

Biomolecules

◐ Carbohydrates: Monosaccharides, Disaccharides, Polysaccharides

Proteins: Amino Acids, Peptide Bonds, Structure of Proteins

◐ Enzymes: Mechanism of Action, Factors Affecting Enzyme Activity

◐ Nucleic Acids: DNA and RNA

Lipids: Fats, Oils, and Waxes

Emerging Topics in Chemistry

◐ Supramolecular Chemistry

◐ Computational Chemistry and Molecular Modeling

◐ Green Synthesis and Sustainable Chemistry

◐ Chemistry of Renewable Energy Sources

Physics

Mechanics

Laws of Motion: Newton’s Laws, Inertia, Momentum

Work, Energy, and Power

Gravitation: Universal Law of Gravitation, Kepler’s Laws

Rotational Motion: Torque, Angular Momentum, Moment of Inertia

Oscillations: Simple Harmonic Motion, Pendulum

Waves: Types of Waves, Wave Equation, Superposition Principle

Thermodynamics

◐ Laws of Thermodynamics

◐ Heat Transfer: Conduction, Convection, Radiation

◐ Thermal Expansion and Specific Heat

◐ Carnot Engine and Thermodynamic Cycles

Kinetic Theory of Gases

Electromagnetism

◐ Electrostatics: Coulomb’s Law, Electric Field, Gauss’s Law

◐ Capacitance and Dielectrics

◐ Current Electricity: Ohm’s Law, Kirchhoff’s Laws, Electrical Circuits

◐ Magnetism: Magnetic Field, Lorentz Force, Biot-Savart Law

◐ Electromagnetic Induction: Faraday’s Law, Lenz’s Law

◐ Alternating Current: AC Circuits, Transformers

Optics

◐ Ray Optics: Reflection, Refraction, Lenses, Mirrors

Wave Optics: Interference, Diffraction, Polarization

◐ Optical Instruments: Microscope, Telescope, Human Eye

◐ Dispersion of Light and Prisms

Modern Physics

◐ Quantum Mechanics: Photoelectric Effect, de Broglie Hypothesis

◐ Atomic Structure: Bohr’s Model, Quantum Numbers

◐ Nuclear Physics: Radioactivity, Nuclear Reactions, Half-Life

◐ Particle Physics: Fundamental Particles, Standard Model

◐ Relativity: Special and General Theory of Relativity

Solid State Physics

◐ Crystal Structure and Lattice Arrangement

◐ Band Theory of Solids: Conductors, Insulators, Semiconductors

◐ Semiconductor Devices: Diodes, Transistors, Integrated Circuits

◐ Superconductivity and Its Applications

Fluid Mechanics

◐ Properties of Fluids: Pressure, Buoyancy, Viscosity

◐ Bernoulli’s Principle and Its Applications

◐ Surface Tension and Capillary Action

◐ Fluid Dynamics: Streamline Flow, Turbulence

Astrophysics and Cosmology

◐ Solar System and Celestial Bodies

◐ Stars and Their Life Cycle

◐ Galaxies and the Universe

◐ Big Bang Theory and Cosmic Microwave Background

Black Holes and Gravitational Waves

Electronics

◐ Basic Electronic Components: Resistors, Capacitors, Inductors

◐ Digital Electronics: Logic Gates, Binary Systems

◐ Communication Systems: Modulation, Demodulation, Satellite Communication

◐ Microprocessors and Microcontrollers

Biophysics

◐ Physics of the Human Body: Biomechanics, Blood Flow

◐ Medical Imaging Techniques: X-rays, MRI, Ultrasound

◐ Radiation Therapy and Its Applications

Nanophysics

Nanomaterials and Their Properties

◐ Applications of Nanotechnology in Physics

◐ Quantum Dots and Nanostructures

Acoustics

◐ Sound Waves: Propagation, Speed, Reflection

◐ Doppler Effect and Its Applications

◐ Ultrasonics and Its Uses

Geophysics

Earth’s Structure and Composition

◐ Seismology: Earthquakes and Seismic Waves

◐ Geothermal Energy and Its Extraction

Plasma Physics

Properties of Plasma

◐ Applications in Fusion Energy

◐ Plasma in Space and Astrophysics

Computational Physics

◐ Numerical Methods and Simulations

Modeling Physical Systems

◐ High-Performance Computing in Physics

Emerging Topics in Physics

◐ Quantum Computing and Information

◐ Dark Matter and Dark Energy

◐ String Theory and Multiverse

◐ Advances in Photonics and Optoelectronics

Information and Communication Technology

Wi-Fi Technology: Principles, Standards, and Applications

◐ Bluetooth: Working Mechanism and Use Cases

◐ 4G Technology: Features, Advantages, and Limitations

◐ 5G Technology: Architecture, Benefits, and Challenges

◐ Satellite Communication: Types, Orbits, and Applications

◐ Broadband Technology: DSL, Fiber Optics, and Wireless Broadband

◐ Internet Protocols: IPv4 vs. IPv6, TCP/IP, UDP

◐ Cloud Computing: SaaS, PaaS, IaaS, and Edge Computing

◐ Internet of Things (IoT): Smart Devices and Connectivity

◐ Artificial Intelligence (AI) in ICT: Chatbots, Automation

◐ Blockchain Technology: Decentralization and Cryptography

◐ Cybersecurity: Threats, Encryption, and Firewalls

◐ Digital Payments: UPI, Mobile Wallets, and Aadhaar Payments

◐ E-Governance: Digital India, MyGov, and UMANG

◐ Social Media: Impact on Communication and Society

◐ Data Privacy and Protection: GDPR, Data Localization

◐ Quantum Communication: Principles and Future Prospects

◐ Augmented Reality (AR) and Virtual Reality (VR) in ICT

◐ ICT in Disaster Management: Early Warning Systems and Coordination

Space Technology

Basics of Space Technology: Rockets, Satellites, and Orbits

◐ Indian Space Program: ISRO’s History and Achievements

◐ Types of Orbits: LEO, MEO, GEO, and Polar Orbits

◐ Launch Vehicles: PSLV, GSLV, and SSLV

◐ Satellite Technology: Communication, Remote Sensing, and Navigation

◐ Chandrayaan Missions: Lunar Exploration by India

◐ Mangalyaan: India’s Mars Orbiter Mission

◐ Gaganyaan: India’s Human Spaceflight Program

◐ Remote Sensing: Applications in Agriculture, Forestry, and Disaster Management

◐ Global Navigation Satellite Systems (GNSS): GPS, GLONASS, Galileo, and NavIC

◐ Space Debris: Challenges and Mitigation Strategies

◐ Reusable Launch Vehicles: ISRO’s RLV-TD Program

◐ Cryogenic Technology: Importance in Space Missions

◐ Space Stations: ISS, Tiangong, and Future Indian Space Station

◐ Planetary Exploration: Missions to Mars, Venus, and Beyond

Astronomy and Astrophysics: Telescopes and Observatories

◐ Space Telescopes: Hubble, James Webb, and AstroSat

◐ Solar Missions: Aditya-L1 and Study of the Sun

◐ Space Weather: Solar Flares, Geomagnetic Storms, and Their Impact

◐ Satellite Communication: VSAT, DTH, and Telemedicine

◐ Military Applications of Space Technology: Surveillance and Reconnaissance

◐ Space Tourism: Current Developments and Future Prospects

◐ Private Space Industry: SpaceX, Blue Origin, and Indian Startups

◐ International Collaboration in Space: Artemis Accords, ISRO-NASA Partnerships

◐ Space Law and Policy: Outer Space Treaty, UNOOSA

◐ Space-Based Solar Power: Concept and Feasibility

◐ Quantum Communication via Satellites: ISRO’s Experiments

◐ Asteroid Mining: Potential and Challenges

◐ Space Colonization: Moon and Mars Habitats

◐ Emerging Technologies: AI in Space Exploration, Space Robotics

Nuclear Technology

Basics of Nuclear Technology: Atomic Structure and Nuclear Reactions

◐ Nuclear Energy: Fission and Fusion Processes

◐ Nuclear Power Plants: Working Principles and Components

◐ India’s Nuclear Program: Three-Stage Nuclear Power Program

◐ Nuclear Reactors: Types (Pressurized Water Reactor, Fast Breeder Reactor)

◐ Nuclear Applications in Medicine: Radiotherapy and Imaging

◐ Nuclear Applications in Agriculture: Mutation Breeding and Pest Control

◐ Nuclear Waste Management: Challenges and Solutions

◐ Nuclear Safety and Security: IAEA Guidelines and India’s Protocols

◐ Global Nuclear Agreements: NPT, CTBT, and India’s Stand

Emerging Technologies

Artificial Intelligence (AI): Machine Learning and Deep Learning

◐ Internet of Things (IoT): Smart Devices and Connectivity

◐ Blockchain Technology: Decentralization and Cryptography

◐ 5G Technology: Features, Applications, and Challenges

◐ Quantum Computing: Principles and Potential Applications

◐ Augmented Reality (AR) and Virtual Reality (VR)

◐ Robotics: Automation and AI-Driven Robots

◐ Biotechnology: CRISPR, Synthetic Biology, and Gene Editing

◐ Nanotechnology: Applications in Medicine, Energy, and Environment

◐ 3D Printing: Additive Manufacturing and Its Uses

Autonomous Vehicles: Self-Driving Cars and Drones

◐ Renewable Energy Technologies: Solar, Wind, and Hydrogen Fuel Cells

◐ Energy Storage: Advanced Batteries and Supercapacitors

◐ Smart Cities: IoT, AI, and Sustainable Urban Development

◐ Cybersecurity: AI-Driven Threat Detection and Prevention

◐ Space Technology: Reusable Rockets and Satellite Constellations

◐ Advanced Materials: Graphene, Metamaterials, and Smart Alloys

◐ Digital Twins: Virtual Models for Real-World Systems

◐ Edge Computing: Decentralized Data Processing

◐ Biometric Technology: Facial Recognition and Fingerprint Scanning

Achievements of India in Science and Technology
  1. Indian Space Program: ISRO’s Milestones (Chandrayaan, Mangalyaan, Gaganyaan)

  2. Launch Vehicles: PSLV, GSLV, and SSLV

  3. NavIC: India’s Indigenous Navigation Satellite System

  4. Aryabhata: India’s First Satellite

  5. Nuclear Technology: Three-Stage Nuclear Power Program

  6. Pokhran Tests: India’s Nuclear Capability

  7. Thorium-Based Nuclear Reactors: Advanced Heavy Water Reactor (AHWR)

  8. Biotechnology: Development of Indigenous Vaccines (Covaxin)

  9. Green Revolution: Agricultural Innovations and High-Yield Crops

  10. White Revolution: Operation Flood and Dairy Development

  11. Information Technology: IT Boom and Global Software Exports

  12. Aadhaar: World’s Largest Biometric ID System

  13. Digital India: Initiatives like UPI, BHIM, and DigiLocker

  14. Supercomputing: PARAM Series and National Supercomputing Mission

  15. Renewable Energy: Solar and Wind Power Leadership

  16. Tejas: Indigenous Light Combat Aircraft (LCA)

  17. INS Vikrant: India’s First Indigenous Aircraft Carrier

  18. BrahMos: Supersonic Cruise Missile Development

  19. Biotechnology: Bt Cotton and Genetically Modified Crops

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